Dr. Walter Pierpaoli on Melatonin – Interviewed by Clive de Carle
Melatonin is produced by the pineal gland and seems to be responsible for the night peak, (while melatonin produced by the gut and the retina does not seem to affect the nocturnal levels). The night peak of melatonin initiates a sequence of positive effects with a cascade of events which maintain the body systems synchronized with the physiological cyclicity of all hormones and cells. Circadian night melatonin produces a resynchronization of the entire hormonal system and improves metabolic and hormonal functions, including blood pressure, cholesterol levels, thyroid, gonad and adrenal functions. Melatonin will counteract the negative side-effects of corticosteroids and of stressful agents, thus protecting the immune system. Melatonin does not induce sleep but facilitates its onset and produces a sleep pattern which is typical of children. Thus it greatly improves the quality of sleep and its restoring physical and psychological effects, with a clear improvement of morning mood and body muscle strength.. Melatonin is found in nature including all cells, plants, animals, tissues and all living organisms. Its night “signal” is essential for the maintenance of immunity and the “surveillance” against the onset of tumors. Therefore melatonin is a fundamental element for prevention of age-related diseases, including cancer, autoimmune and cardiovascular diseases. Melatonin cannot be considered a classical “hormone” because it does not possess any of the qualities of the classical hormones such as growth hormone, cortisone, estrogens, thyroid hormones etc. Rather it modulates and controls the synthesis and secretion of all hormones within a circadian and seasonal periodicity. It is this correction of the circadian clock that enables the restoration and correction of the derangements to enable maintenance of original juvenile conditions. Melatonin Zn-Se is suitable to resynchronize all hormonal functions and Melatonin Zn-Se contains synergistic elements to obtain more rapid effects and to compensate the loss of fundamental minerals, due to bad diet or to aging. Zinc Many studies have observed that zinc can correct aging-dependent immuno-depression and several other hormonal and metabolic alterations typical of aging. Zinc is an essential component of more than 200 enzymes and one of the most important trace elements in the body. Studies of Dr. Pierpaoli and co-workers have shown that melatonin alone produces an increase of zinc levels in the blood of old animals. This important observation of the powerful antiaging and immuno-enhancing activity of the combination of zinc and melatonin has resulted into the development of Melatonin Zn-Se. Selenium Selenium is a fundamental trace element of the body and possesses powerful anti-cancer effects. Modern agriculture and alimentary habits have dramatically decreased the quantity of selenium from the diet. Selenium is essential for the enzymatic reaction responsible for the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage. A lack of selenium will thus result in a loss of the detoxification capacity of the body, immunodepression and onset of degenerative diseases and cancer. This is the reason why Melatonin Zn-Se combines these 3 fundamental antiaging molecules of melatonin, zinc and selenium. Whilst melatonin plays the master role for reactivation and restoration of the natural night peak to juvenile levels, (thus resulting into the normalization of all measurable immunological and endocrine functions), the positive age-postponing, metabolic and immunological effects of Melatonin Zn-Se becomes progressively more visible and remarkable. In time, the “program of aging” can be slowed with regular nocturnal use of Melatonin Zn-Se.”
